Extended Structure- Activity Relationship of 1,5-Disubstituted Tetrazoles: Synthesis, Antiproliferative Activity, and Molecular Docking Studies
Department
Chemistry
Advisor
Dr. Baker Jawabrah Al Hourani, PhD
Document Type
Poster
Start Date
2-26-2025 2:00 PM
End Date
2-26-2025 5:00 PM
Abstract
Cyclooxygenase (COX) is an enzyme that exists as two isoforms within the body: COX-1 and COX-2. COX-1 is constitutively expressed and plays a key role in maintaining homeostatic functions, including the regulation of renal blood flow and platelet aggregation. In contrast, COX-2 is induced in response to inflammation and other physiological stimuli, leading to the production of prostaglandins, which mediate pain and drive the inflammatory process. Chronic inflammation is linked to various diseases, such as cardiovascular disease, diabetes, and cancer, making COX-2 a critical therapeutic target. In this study, a series of novel 1,5-disubstituted tetrazoles were synthesized and will be evaluated for their biological activity against cancer cell lines, as well as their molecular interactions through docking studies. The findings will provide insight into the therapeutic potential of these compounds as selective COX-2 inhibitors for anticancer and anti-inflammatory applications.
Recommended Citation
Smith, Brian, "Extended Structure- Activity Relationship of 1,5-Disubstituted Tetrazoles: Synthesis, Antiproliferative Activity, and Molecular Docking Studies" (2025). Day of Scholarship. 20.
https://spark.bethel.edu/dayofscholarship/spring2025/feb26/20
Extended Structure- Activity Relationship of 1,5-Disubstituted Tetrazoles: Synthesis, Antiproliferative Activity, and Molecular Docking Studies
Cyclooxygenase (COX) is an enzyme that exists as two isoforms within the body: COX-1 and COX-2. COX-1 is constitutively expressed and plays a key role in maintaining homeostatic functions, including the regulation of renal blood flow and platelet aggregation. In contrast, COX-2 is induced in response to inflammation and other physiological stimuli, leading to the production of prostaglandins, which mediate pain and drive the inflammatory process. Chronic inflammation is linked to various diseases, such as cardiovascular disease, diabetes, and cancer, making COX-2 a critical therapeutic target. In this study, a series of novel 1,5-disubstituted tetrazoles were synthesized and will be evaluated for their biological activity against cancer cell lines, as well as their molecular interactions through docking studies. The findings will provide insight into the therapeutic potential of these compounds as selective COX-2 inhibitors for anticancer and anti-inflammatory applications.
